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Abstract
Man's exposure to many chemicals can be assessed by analysis of blood and urine. Lipophilic compounds such as chlorinated hydrocarbons are typically analyzed in blood or body fat. More polar compounds, or those that are rapidly metabolized to phenols or acids, can be determined in the urine. The use of animal model systems can provide valuable information about the metabolism, storage, and excretion patterns of toxic chemicals to which man is exposed, as well as a means of estimating prior exposure.