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Abstract
Delta‐9‐tetrahydrocannabinol (?9‐THC) either alone or in conjunction with known mutagens was investigated for either excitatory or inhibitory effects on the mutation rate of Salmonella typhimurium LT2 strains TA1538, TA1537, TA1535, TA100 and TA98 in the standard Salmonella/microsomal testing system.
The Salmonella strains were subjected to non‐toxic concentrations of ?9‐THC in conjunction with three known mutagens and one promutagen that are routinely used as positive controls in Salmonella/microsomal testing. The mutagens were 4‐nitro‐o‐phenylene diamine for strains TA1538 and TA98, sodium azide for strains TA1535 and TA100, and 9‐aminoacridine for strain TA1537; the promutagen was 2‐amino‐anthracene for all five bacterial test strains. A growth study was performed in establishing the toxicity of ?9‐THC and its dose‐dependency.
Results showed that in Salmonella strains TA1538 and TA100 ?9‐THC treated experimental values were significantly lower than the non‐?9‐THC treated positive control values. Thus ?9‐THC had a diminishing effect on the induced mutation rate in these two strains”;. The results when utilizing the other three Salmonella strains (TA1537, TA1535, and TA98) indicated some repression of mutation rate, depending on the concentration of ?9‐THC being employed. However, the results obtained for these three strains were not statistically different from the positive non‐?9‐THC treated control values.
Notes
Department of Biological Sciences, Health Science Division, Box 22, 690A East Tennessee State University, Johnson City, Tennessee 37614