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Abstract
The class of organometallic compounds was studied in order to nominate chemicals to the National Cancer Institute as candidates for carcinogen bioassay. A preliminary list of 1,815 candidate chemicals was developed for four major subclasses: (1) alkyl organometallics; (2) aryl organometallics, coordination compounds, and miscellaneous organometallics; (3) organosilicon compounds; and (4) organophosphorus compounds. Based on an evaluation of both the evidence Indicating possible suspicion of carcinogenic activity and evidence indicating potential human exposure, the following five nominations were made: chromium carbonyl, ferrocene, ferric ammonium ferrocyanide, triphenylantimony, and the representative organosilicons, octamethyltrisiloxane, and octamethylcyclotetrasiloxane.
Notes
Reprints may be obtained from Dr. C. T. Helmes and also from Dr. H. F. Kraybill, Scientific Coordinator for Environmental Cancer, Division of Cancer Cause and Prevention, National Cancer Institute, Landow Building, Room C337, 7910 Woodmont Avenue, Bethesda, Maryland 20205