Translocation of intratracheally administered ⁸⁹Sr enriched fly ash into extrapulmonary organs in rats

Abstract

The distribution of intratracheally administered fly ash into extrapulmonary organs of rats at various periods has been studied by giving ⁸⁹Sr‐enriched fly ash of respirable particles size. The organs studied were liver, brain, heart, spleen, kidney, stomach, small intestine and plasma. The ⁸⁹Sr‐radioactivity appeared in all these tissues and was maximum at 12 hrs period. The translocation 89 of ⁸⁹Sr‐radioactivity from lung occured in two phases one a rapid one and the other a slow one. Similar pattern of decline in ⁸⁹Sr‐radioactivity was obtained in extrapulmonary organs and plasma. A gradual but steady increase of ⁸⁹Sr‐enriched fly ash radioactivity was found in the trichloro acetic acid (TCA) precipitable fraction.

Key words:

• ⁸⁹Sr‐enriched fly ash
• intratracheal
• Translocation
• Extrapulmonary organs
• ⁸⁹Sr radioactivity

Notes

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