The effects of ascorbic acid on copper‐induced oxidative changes in human erythrocytes: Example of a biphasic dose‐response relationship

Abstract

In an in vitro study, ascorbic acid reduced the occurrence of copper acetate‐induced oxidative stress in human erythrocytes at biologically relevant concentrations (0.06 ‐ 0.25 mM) while enhancing oxidative changes [i.e., changes in methemoglobin (METHB) and reduced glutathione (GSH)] at higher levels of exposure (> 1.0 mM).

Key words:

• ascorbic acid
• copper
• erythrocyte