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Abstract
Six pesticides were examined for oxidant Stressor effects on Dorset sheep erythrocvtes, an animal model with low glucose‐6‐phosphate dehydrogenase (G‐6‐PD) activity. The pesticides tested were atrazine, azinphos‐methyl, methomyl, parathion, propoxur and zineb. A liver microsomal enzyme system was used to generate metabolites of the parent compounds. The blood parameters measured were reduced glutathione (GSH) levels and methemoglobin formation.
The results indicated that metabolites of the six pesticides were not oxidant Stressor agents towards G‐6‐PD deficient erythrocytes, in vitro. The pesticides, zineb and parathion, incubated without the microsomal enzyme system, did exert statistically significant oxidizing effects on the G‐6‐PD deficient erythrocytes.