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Abstract
The hormone, dehydroepiandrosterone (DHEA), has been shown to inhibit red blood cell and tissue G‐6‐PD activity levels, in vitro. Red blood cell samples fron six adult human subjects were collected in order to evaluate DHEA‐treated erythyrocyte responses to the oxidant stressor agent, acetylphenylhydrazine (APH). Human erythrocytes were incubated with DHEA for half an hour, then with with 0.5 to 5.0 mg APH for one to two hours. Methemoglobin and reduced glutathione levels were measured after incubation. The erythrocytes treated with DHEA were sensitive to the oxidant Stressor effects of all levels of APH, compared to the responses of normal red blood cells. However, erythrocytes treated with the ethyl alcohol carrier were similarly sensitive to the oxidizing effects of APH.