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Abstract
It was hypothesized that the antineoplastic drug (1, 3‐bis(2‐chloroethyl)‐i‐nitrosourea (BCNU), a known and potent Inhibitor of erythrocyte glutathlone reductase (GSSG‐R), may enhance the oxidant stress of known oxidizing agents commonly found in the environment. Consequently, this paper assessed the effects of BCNU‐induced decreases (i.e. down to approximately 20% of normal) In human erythrocyte GSSG‐R on the toxicity of six known oxldant stressor agents (i.e. chlorite, copper, nitrite, p‐chloroaniline, paraquat and carbaryl) as measured by changes in methemoglobin (METHB) and reduced glutathlone (GSH). The results Indicated that a BCNU‐induced deficiency of GSSG‐R produced no enhanced formation of METHB or decrease in GSH under exposure to the above stressors.