Fabricating of Fe₃O₄@Ag-MOF nanocomposite and evaluating its adsorption activity for removal of doxorubicin

Abstract

The purpose of this research was to investigate the doxorubicin (DOX) adsorption behavior on Fe3O4@Ag-Metal Organic Framework (Fe₃O₄@Ag-MOF). This adsorbent was effectively prepared using a simple synthetic process. Many instruments, including FTIR, XRD, SEM, TEM, and XPS, were used to characterized the new Fe₃O₄@Ag-MOF. Additionally, the presented Fe₃O₄@Ag-surface MOF's area was shown to be 586.06 m2/g with a size of around 43 nm. The composite that was made has magnetic properties that were quite strong (63.3 emu/g). The produced Fe₃O₄@Ag-MOF was discovered to have a fantastic ability to adsorb the anti-cancer drug DOX, with a 1.72 mmol/g (934.85 mg/g) adsorption capacity. On the basis of changes in temperature, pH, and DOX concentration, the DOX adsorption behavior mechanism was investigated. The adsorption capacity of Fe₃O₄@Ag-MOF for DOX was greater at pH 7.0, according to experimental data. The adsorption equilibrium also demonstrated that the Langmuir adsorption was regulated the best fit to the extracted data compared with the other models. Additionally, the activation energy of adsorption for DOX onto Fe₃O₄@Ag-MOF was determined, indicating the chemisorption process. The adsorption kinetics was shown in the well-known kinetic model of the pseudo-second-order. The adsorption thermodynamic measurements were documented according to according to the enthalpy (ΔH°), entropy(ΔS°), and Gibbs free energy (ΔG°) parameters demonstrated that the reaction was endothermic and spontaneous thermodynamic. The adsorption of DOX onto Fe₃O₄@Ag-MOF from real water samples (tap water, effluent wastewater, and influence wastewater) were investigated. It’s interesting that the synthetic adsorbent had great recyclability 72.6 percent in the fifth cycle indicating that it was highly recyclable. After adsorption, the typical Fe₃O₄@Ag-MOF XRD peak intensities and locations were mostly unchanged throughout adsorption indicates the crystalline phase remained steady. The results indicated that Fe₃O₄@Ag-MOF were a good candidate for adsorbing the DOX and treating wastewater.

Keywords:

• Adsorption
• magnetic composite
• doxorubicin hydrochloride
• isotherm
• kinetics

Acknowledgments

The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: (22UQU4350527DSR08).

Additional information

Funding

The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: (22UQU4350527DSR08).