Tissue distribution of selenate, selenite, selenocystine, and selenomethionine in mice

Abstract

This study reports the tissue distribution of Se in female mice. Mice were injected intraperitoneally with a single sublethal dosage (5 mg Se/kg) of four different forms of Se: selenate, selenite, selenocystine, and selenomethionine. The mice were sacrificed at various times over a 24‐hour period following injection. Selenium concentrations in seven different tissue types were determined fluorometrically. Data indicated that the organic or inorganic forms of Se affected the concentrations of Se in sampled tissues. Selenite and selenocystine were noted to have similar distribution patterns. In all tissues sampled, selenate and selenomethionine produced the greatest concentrations of Se. Two maximum peaks of Se were observed in some tissues.

Notes

To whom correspondence should be addressed.