The effects of some pesticites on the activity of liver and erythrocyt enzymes (in vitro)

Abstract

The effect of pomarsol (tetramethyltriurem disulphide), Benlate 1‐(N‐Butlycarbomoyl) 2‐(Metoxycarboxamido)‐bezimidazol, meothrin (α‐cyanophenoxbenzyl 2.2.3.3.‐tetramethyI cyclopropanecarbonylate), Imperator [α‐cyano 3‐phenoxybenzylcis, trans‐3‐ (2.2‐dichroinyl)‐2.2‐ dimetil research on GOT, GPT (liver enzymes) and CA‐I, CA‐II (Human erythrocyt) BCA (Bovine erythrocyt). Among the chemicals meothrin, imperator, sumicidin were determined to have inhibitory effect, on bovine CA, human CA and GOT enzymes, but ineffective on GPT enzyme. The I₅₀ values of chemicals caused inhibition were determined by means of activity percentage [I] diagrams. The values were 3.2×10^‐2 M, 3.5×10^‐2 M, 2.7×10^‐2 M for GOT respectively. The values of same chemicals were 5.8×10^‐3 M, 1.00×10^‐2 M, 1.22×10^‐2 M for CA‐I, and 7.1 1×10^‐2 M, 2.68×10^‐2 M, 1.22×10^‐2 M for CA‐II respectively on the order hand, these chemical were 9.25×10^‐3 M, 8.65×10^‐3 M and 1.63×10^‐2 M for bovine CA.

Key words:

• Pesticites
• Inhibitör
• Enzymes