Abstract
The carbonic anhydrase isoenzymes employed here have been purifield in high yields by affinity chromatograpy using different affinity gels(Sepharose4B‐L‐tyrosine‐Benzensulfonamide). Inhibition effect of 2‐Substituted‐l,3,4‐Thiadiazole‐5‐Sulfonamides on human carbonic anhydrase‐I (HCA‐I) and bovine carbonic anhydrase (BCA) have been determined. It was found that inhibition effects of these compounds on BCA and CA‐I were very great.
Key words: