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Original Articles

Affinity to some inhibitors of human carbonic anhydrase‐i and bovine carbonic anhydrase

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Pages 2017-2022 | Received 21 Mar 1996, Published online: 15 Dec 2008
 

Abstract

The carbonic anhydrase isoenzymes employed here have been purifield in high yields by affinity chromatograpy using different affinity gels(Sepharose4B‐L‐tyrosine‐Benzensulfonamide). Inhibition effect of 2‐Substituted‐l,3,4‐Thiadiazole‐5‐Sulfonamides on human carbonic anhydrase‐I (HCA‐I) and bovine carbonic anhydrase (BCA) have been determined. It was found that inhibition effects of these compounds on BCA and CA‐I were very great.

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