In issue 16(3-4) of the Journal of Toxicology and Environmental Health, Part B, in the article “Pesticide Exposure and Neurodevelopmental Outcomes: Review of the Epidemiologic and Animal Studies” by Carol J. Burns, Laura J. McIntosh, Pamela J. Mink, Anne M. Jurek, and Abby A. Li, corrections to , 14, 16 and 18 were discovered by the authors post-publication.
TABLE 10. Organophosphate in vivo mammalian studies (rows with corrections)
In most cases, the errors were related to incorrect selection of Endnote references and slight miscounting of studies with different characteristics. In two cases, the NOEL/LOELs were corrected to higher dose levels, and, hence, higher than the reference doses listed in the “Regulatory Number” column. For 3 organophosphates from , the row(s) needing corrections are presented in tabular form for clarity. None of these changes impact the scientific conclusions of this review paper.
References in footnotes “e” and “f” (We include all the references for each author citation for which there was at least one missing or incorrect reference):
eChlorpyrifos gestation-only references: Aldridge et al., 2003, 2004, 2005b, Slotkin and Seidler, 2007a.
fChlorpyrifos PND direct dosing references: Ricceri et al., 2003, 2006, Slotkin et al., 2001, 2002, 2004, 2006a, CitationSlotkin and Seidler, 2005, Venerosi et al., 2006, 2008, Tang et al. 1999.
Diazinon “gestation only” unit of analysis was litter of origin: 0 studies
Trichlorfon “gestation only” unit of analysis was litter of origin: 1 study
Additional corrections made in the abbreviated below.
TABLE 14
Chlordecone
PND direct dosing: offspring NOEL for Gray et al. 1982 is 0.25 mg/hamster pup (PND 4) instead of 0.25 mg/kg body weight. Since hamster pup weights were not provided to convert to mg/kg, the lowest NOEL is changed to 22 mg/kg based on Tilson et al. 1982 (dose level of 0.2 mg/ rat pup and PND 4 rat pup weights of 9-10 g from of that paper).
Gestation and PND: 3 (not 2) studies had dose response data; lowest LOEL was 0.1 mg/kg body weight based on EPA IRIS (2009) conversion from 1 ppm in diet (Squibb 1982; U.S. EPA, 2009 http://www.epa.gov/iris/toxreviews/1017tr.pdf)
PND through dams >6 litters/dose group: 0 studies
Endosulfan
PND direct dosing >6 litters/dose group: 1 study
Gestation and PND >6 litters/dose group: 0 studies
Heptachlor
Gestation only >6 litters/dose group: 1 study
TABLE 16
Allethrin:
PND direct dosing > 6 litters/dose group: 0 studies
TABLE 18
Atrazine: Exposure period is gestation with or without PND exposure because Belloni et al., 2011 included both gestation and PND exposure.
Paclobutrazol: Exposure period is GD only; litter was unit of analysis for 0 studies
Piperonyl butoxide: litter was unit of analysis for 1 study
REFERENCES (missing from paper)
- Ricceri , L. , Markina , N. , Valanzano , A. , Fortuna , S. , Cometa , M. F. , Meneguz , A. and Calamandrei , G. Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice . Toxicol. Appl. Pharm , 191 189 – 201 .
- Slotkin , T. A. and Seidler , F. J. 2005 . The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent . Dev. Brain. Res , 158 : 115 – 119 .
- Slotkin , T. A. and Seidler , F. J. 2007b . Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats . Brain. Res. Bull , 75 : 640 – 647 .
- Venerosi , A. , Cutuli , D. , Colonnello , V. , Cardona , D. , Ricceri , L. and Calamandrei , G. 2008 . Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood . Neurotoxicol. Teratol , 30 : 468 – 474 .
- U.S. Environmental Protection Agency. 2009. Toxicological review of chlordecone (kepone). EPA/635/R-07/004F http://www.epa.gov/iris/toxreviews/1017tr.pdf (http://www.epa.gov/iris/toxreviews/1017tr.pdf)