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Journal of Toxicology and Environmental Health, Part B
Critical Reviews
Volume 23, 2020 - Issue 7
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Review

Effects of ambient particulate matter on vascular tissue: a review

Kristina Shkirkovaa Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9288-4258View further author information
ORCID Icon,
Krista Lamorie-Footea Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAView further author information
,
Michelle Connora Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAView further author information
,
Arati Patela Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAORCID Iconhttps://orcid.org/0000-0002-2300-0391View further author information
ORCID Icon,
Giuseppe Barisanoa Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USAView further author information
,
Hans Baertscha Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAView further author information
,
Qinghai Liua Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USAView further author information
,
Todd E. Morganc Department of Gerontology, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USAView further author information
,
Constantinos Sioutasd Department of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, USAView further author information
&
William J. Macka Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USA;e Department of Neurosurgery, University of Southern California, Los Angeles, CA, USAView further author information
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Pages 319-350 | Published online: 24 Sep 2020
 
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ABSTRACT

Fine and ultra-fine particulate matter (PM) are major constituents of urban air pollution and recognized risk factors for cardiovascular diseases. This review examined the effects of PM exposure on vascular tissue. Specific mechanisms by which PM affects the vasculature include inflammation, oxidative stress, actions on vascular tone and vasomotor responses, as well as atherosclerotic plaque formation. Further, there appears to be a greater PM exposure effect on susceptible individuals with pre-existing cardiovascular conditions.

Highlights

  1. We review the current literature and outline the effects of particulate matter (PM) on vascular tissue.

  2. PM exposure induces inflammation, vasoconstriction, oxidative stress, and atherosclerotic plaque formation.

  3. PM exposure is particularly detrimental to individuals with underlying cardiovascular conditions.

  4. Further studies examining the vascular effects of specific PM compositions, concentrations, and particle sizes are warranted.

Authors’ contributions

KS performed literature search and contributed to writing and revision of the manuscript. KLF, MC, AP performed section specific literature searches and contributed to writing parts and revising the manuscript. GB, HB, QL performed literature searches and helped with tables and figures preparations. TEM and CS contributed to manuscript revisions and critical comments and edits. WJM contributed to manuscript writing, revision, editing and critical assessment. All authors read and approved the final manuscript.

Acknowledgments

The authors are grateful for the valuable critical comments by Caleb E. Finch (USC) and Henry J. Forman (USC).

Competing interests

No competing interests to report

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

National Institute on Aging - PO1-AG055367 National Institute of Environmental Health Sciences - RO1-ES024936

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