Pharmacodynamics of Antimicrobial Agents and Rationale for Their Dosing

A.P. MacgowanBristol Centre for Antimicrobial Research and Evaluation, Southmead Health Services NHS Trust and University of Bristol, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, BS10 5NB, UK. Tel: +44.117.959 5652; Fax: +44.117.959 3154.

K.E. BowkerBristol Centre for Antimicrobial Research and Evaluation, Southmead Health Services NHS Trust and University of Bristol, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, BS10 5NB, UK. Tel: +44.117.959 5652; Fax: +44.117.959 3154.

Summary

Antimicrobial pharmacodynamics are an area of considerable importance in terms of dose regimen optimisation and clinical outcome. The pharmacodynamic properties of penicillins, cephalosporins, carbapenems, quinolones, glycopeptides and aminoglycosides are reviewed; the impact such knowledge may have in the future on how we dose these agents is discussed.

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