How to Study Boron Biodistribution in Liver Metastases from Colorectal Cancer

L. RovedaHepato-Pancreatic Surgery, IRCCS Pol. S. Matteo, Pavia

U. PratiExperimental Surgery, IRCCS Pol. S. Matteo, Pavia

J. BakeineExperimental Surgery, IRCCS Pol. S. Matteo, Pavia

F. TrottaHepato-Pancreatic Surgery, IRCCS Pol. S. Matteo, Pavia

P. MarottaHepato-Pancreatic Surgery, IRCCS Pol. S. Matteo, Pavia

P. ValsecchiHepato-Pancreatic Surgery, IRCCS Pol. S. Matteo, Pavia

A. ZontaDept. of Surgery, University of Pavia

R. NanoDepartment of Animal Biology, Department of Histochemistry and Cytochemistry, University of Pavia and IGM-CNR, Pavia

A. FacoettiDepartment of Animal Biology, Department of Histochemistry and Cytochemistry, University of Pavia and IGM-CNR, Pavia

P. ChiariDepartment of Animal Biology, Department of Histochemistry and Cytochemistry, University of Pavia and IGM-CNR, Pavia

S. BarniDepartment of Animal Biology, Department of Histochemistry and Cytochemistry, University of Pavia and IGM-CNR, Pavia

T. PinelliINFN, Pavia and Dept. of Nuclear and Theoretical Physics, IUniversity of Pavia, Italy.

S. AltieriINFN, Pavia and Dept. of Nuclear and Theoretical Physics, IUniversity of Pavia, Italy.

A. BraghieriINFN, Pavia and Dept. of Nuclear and Theoretical Physics, IUniversity of Pavia, Italy.

P. BruschiINFN, Pavia and Dept. of Nuclear and Theoretical Physics, IUniversity of Pavia, Italy.

F. FossatiINFN, Pavia and Dept. of Nuclear and Theoretical Physics, IUniversity of Pavia, Italy.

P. PedroniINFN, Pavia and Dept. of Nuclear and Theoretical Physics, IUniversity of Pavia, Italy.

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Summary

The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: a particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.

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How to Study Boron Biodistribution in Liver Metastases from Colorectal Cancer

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How to Study Boron Biodistribution in Liver Metastases from Colorectal Cancer

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