Interstitial Radiosurgery with the Photon Radiosurgery System in the Minimally-Invasive Treatment of Selected Deep-Seated Brain Tumors

N. Di LorenzoDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.Correspondence[email protected]

C. CavedonDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.

F. PaierDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.

A. CompagnucciDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.

A.M. BuccolieroDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.

G. PansiniDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.

P. FrancesconDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.

P. GallinaDepartment of Neurosurgery, Department of Radiation Oncology, Department of Medical Physics and Department of Human Pathology, University of Florence, Florence, Italy.;Department of Medical Physics, S. Bortolo Hospital, Vicenza, Italy.

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Summary

The purpose of this study was to evaluate the results of interstitial radiosurgery (IR) with Photon Radiosurgery System (PRS) in 18 patients (P) with deep-seated brain primary or secondary tumors. Follow-up varied from 2 to 53 months (mean, 13.6 mo). Seven P with glioblastomas died due to tumor progression. Five P with metastases died for systemic disease while local control was achieved in all. Six P with low-grade astrocytomas were well and imaging showed tumor control. We conclude that PRS IR is effective in the treatment of metastases while it provides lower benefit in malignant gliomas. It could play a major role in low-grade astrocytomas.

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Interstitial Radiosurgery with the Photon Radiosurgery System in the Minimally-Invasive Treatment of Selected Deep-Seated Brain Tumors

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Interstitial Radiosurgery with the Photon Radiosurgery System in the Minimally-Invasive Treatment of Selected Deep-Seated Brain Tumors

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