Therapeutic Drug Monitoring of Gentamicin in Neonatal Intensive Care Unit: Experience in 68 Newborns

M. TestaIstituto di Patologia e Terapia Intensiva Neonatale -Puericultura e Nido-Università di Cagliari, Italy.

V. FanosIstituto di Patologia e Terapia Intensiva Neonatale -Puericultura e Nido-Università di Cagliari, Italy.

V. MartinelliIstituto di Patologia e Terapia Intensiva Neonatale -Puericultura e Nido-Università di Cagliari, Italy.

M. StronatiIstituto di Farmacologia - Università degli Studi di Cagliari, Italy.

M. MussapTerapia Intensiva Neonatale, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

M. Del ZompoLaboratorio Centrale, Ospedale San Martino, Genova, Italy.

Summary

A proper dosing regimen is fundamental when antibiotics with a low therapeutic index, as aminoglycosides (AMG), are used. AMG pharmacokinetics present a strong interindividual and intraindividual variability in neonates; in the premature neonate AMG clearance is reduced and the half-life is longer, leading to higher serum trough concentrations. Neonates may require therapeutic drug monitoring (TDM) and a “tailored” therapeutic regimen. The aim of this work is to present our personal experience with TDM of gentamicin in 68 newborns and to compare it with data available in the literature.

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Therapeutic Drug Monitoring of Gentamicin in Neonatal Intensive Care Unit: Experience in 68 Newborns

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