In vitro activity of ceftaroline and ceftobiprole against methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin isolated in paediatric patients

Abstract

Minimal inhibitory concentrations (MIC, mg/l) of ceftaroline and ceftobiprole were evaluated over 70 methicillin-resistant Staphylococcus aureus (MRSA) strains with vancomycin MIC ≥1 isolated in a paediatric hospital. The proportion of non-wild-type strains (MIC > epidemiological cut off) was 18% for ceftobiprole and 64% for ceftaroline. Only 1.4% of strains was resistant to ceftobiprole, and none to ceftaroline. These results are worrisome, since show the presence of non-negligible proportions of MRSA strains with high MIC values for ceftaroline and ceftobiprole in a setting where both drugs were never used.

Keywords:

• Ceftaroline
• ceftobiprole
• methicillin-resistant Staphylococcus aureus
• minimal inhibitory concentrations
• paediatrics

Disclosure statement

E. C. participated to a Basilea Pharmaceutica advisory board for ceftobiprole. Other authors report no declarations of interest.

Supplementary material

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Additional information

Notes on contributors

Giulia Carnesecchi

Giulia Carnesecchi: PhD, has completed its training in Microbiology the Microbiology Section of the Laboratory of Analysis of IRCCS Istituto Giannina Gaslini

Raffaele Lobello

Raffaele Lobello, PhD, has completed its training in Microbiology the Microbiology Section of the Laboratory of Analysis of IRCCS Istituto Giannina Gaslini

Laura Liggieri

Laura Liggeri: PhD, has completed its training in Microbiology the Microbiology Section of the Laboratory of Analysis of IRCCS Istituto Giannina Gaslini

Candida Palmero

Candida Palmero: PhD, the Microbiology Section of the Laboratory of Analysis of IRCCS Istituto Giannina Gaslini

Luisa Pescetto

Luisa Pescetto: PhD, works in the Microbiology Section of the Laboratory of Analysis of IRCCS Istituto Giannina Gaslini

Patrizia Morelli

Patrizia Morelli: PhD, the Microbiology Section of the Laboratory of Analysis of IRCCS Istituto Giannina Gaslini and is referent for Microbiology in patients with cystic fibrosis

Elio Castagnola

Elio Castagnola: MD, PhD, specialists in Infectious Diseases and Pediatrics, works as consultant for infections in immunocompromised children, cystic fibrosis and infections in neonates. At present is the chief of the Infectious Diseases Unit of IRCCS Istituto Giannina Gaslini

Roberto Bandettini

Roberto Bandettini: specialist in Microbiology. He is currently responsible for the Microbiology Section of the Laboratory of Analysis of IRCCS Istituto Giannina Gaslini