Common microbial causes of significant bacteriuria and their antibiotic resistance pattern in the Isfahan Province of Iran

Abstract

Urinary tract infections (UTIs) are considered the most common community-acquired infections worldwide, which have possible complications along with significant economic impact on national healthcare systems. The aim of this study was to identify the most common causes of significant bacteriuria and to assess their antimicrobial resistance pattern in the Isfahan province of Iran. In this cross-sectional study, 11,678 urine samples of the patients referred to Mahdieh Medical Diagnostic Centre Charity were examined over a period of 10 months (from September 2015 to June 2016). Among the cases, 6.85% were positive for bacteriuria (F/M = 11.3). Escherichia coli (62%) was the most frequently isolated bacteria, followed by Staphylococcus epidermidis (13.9%) and Staphylococcus aureus (6.8%). E. coli was more prevalent among patients with diabetes mellitus. E. coli isolates showed the highest resistance to nalidixic acid, Trimethoprim/Sulfamethoxazole and Cefixime. Our results revealed that broad-spectrum antibiotic resistance is frequent among isolated uropathogens in Isfahan, Iran.

Keywords:

• Bacteriuria
• Antimicrobial resistance
• Infection

Acknowledgements

This study was supported in part by Mahdieh Medical Diagnostic Centre Charity, Isfahan, Iran. Authors are grateful of University of Isfahan for its support. Authors would like to thank Dr. Mohammad Eslamian (M.D.) and Dr.Hamed Samadzadeh (Pharm.D.) for their support and assistance.

Conflicts of interest

All authors declare to have no conflict of interest.

Additional information

Notes on contributors

Masoud Edalati

Edalati (M.E) wrote the article in whole, proposed the idea, contributed in data analysis, and revised the article. Pezeshki (M.P) helped in data gathering and analysis. She also helped in manuscript writing in part. Dagoohian (A.D) helped in data gathering. Rajaie (S.R) also helped in data gathering. Zarkesh-Esfahani (S.H.Z) contributed in writing and editing the article.