First case of Abiotophia defectiva infectious endocarditis treated with a combination of amoxicillin and daptomycin

Abstract

Abiotophia defectiva (A. defectiva) infectious endocarditis (IE) is a serious disease that usually requires lengthy treatment with a combination of amoxicillin and gentamicin. Since severe nephrotoxicity can be associated with prolonged administration of gentamicin, the alternative use of daptomycin in combination with amoxicillin can be considered. We present the case of a 51-year-old man that presented an A. defectiva endocarditis on an aortic bicuspidy. Diagnosis of cirrhosis was made simultaneously, and therefore gentamicin was counter-indicated. A combination of amoxicillin 12 g per day and daptomycin 700 mg (10 mg/kg) was administrated, with resolution of clinical, biological and echographic abnormalities, and no relapse after 1 year. In our experience, amoxicillin with daptomycin could be an alternative in case of A. defectiva IE with counter-indication to aminoglycosides.

Keywords:

• Abiotrophia defectiva
• endocarditis
• infection
• daptomycin
• aminoglycoside

Acknowledgments

Authors are deeply indebted to Juliusz Chroboczek for his help with proof reading.

Conflict of interest

No financial support was received, and none of the authors has a conflict of interest concerning this report.

Notes on contributors

Tomasz Chroboczek (MD) is an infectious diseases specialist. He works in the infectious diseases department of the Centre HospitalierAlpes Léman, in Contamine sur Arves, France.Julie Le Scanff (MD) is an internal medicine specialist. She works in the internal medicine department of the Hôpital Nord Ouest, in Villefranche sur Saône, France.Gary David (MD) is an infectious diseases specialist. He currently heads the infectious diseases department of the Hôpital Nord Ouest, in Villefranche sur Saône, France.