Emerging roles of ncRNAs regulating ABCC1 on chemotherapy resistance of cancer – a review

Abstract

In the process of chemotherapy, drug resistance of cancer cells is a common and difficult problem of chemotherapy failure, and it is also the main cause of cancer recurrence and metastasis. Non-coding RNAs (ncRNAs) refer to the RNA that does not encode proteins, including microRNA (miRNA), long non-coding RNA (lncRNA) and circularRNA (circRNA), etc. NcRNAs are involved in a series of important life processes and further regulate the expression of ABCC1 by directly or indirectly up-regulating or down-regulating the expression of targeted mRNAs, making cancer cells more susceptible to drug resistance. A growing number of studies have shown that ncRNAs have effects on cancer cell proliferation, invasion, metastasis, and drug sensitivity, by regulating the expression of ABCC1. In this review, we will discuss the emerging roles of ncRNAs regulating ABCC1 in chemotherapy resistance and mechanisms to reverse drug resistance as well as provide potential targets for future cancer treatment.

Keywords:

• Cancer
• chemotherapy
• miRNA
• lncRNA
• circRNA
• ABCC1

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was funded by the National College Students Innovation and Entrepreneurship Training Program [grant number 202210555100], the Hengyang City Science and Technology Planning Project [grant number 202150063473], the Scientific Research Project of Hunan Provincial Health Commission [grant number 202202044140], the Scientific Research Project of Hunan Provincial Education Department [grant number 21B0438].