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Abstract
A dynamic model has been developed to quantitate the dynamics of growth of Escherichia coli. The model integrates the pre-existing models of chromosome replication and cell division by incorporating a description of the synthesis and degradation of ribosomes and protein. Relevant features of the model are: a threshold control for DNA synthesis and a double feedback mechanism that controls ribosome synthesis.
The model generates accurate predictions of the kinetics of growth and cell composition of Escherichia coli B/r cells, each growth condition being defined by a set of parameters.