Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters

Eun Jeong WonDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea; ;Department of Parasitology and Tropical Medicine, Chonnam National University Medical School, Gwangju, Korea;

http://orcid.org/0000-0002-8750-4257

Min Young JooDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea;

Dain LeeDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea;

http://orcid.org/0000-0003-0236-9808

Mi-Na KimDepartment of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea;

Yeon-Joon ParkDepartment of Laboratory Medicine, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea;

Soo Hyun KimDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea; ;Department of Microbiology, Chonnam National University Medical School, Gwangju, KoreaCorrespondence[email protected]

http://orcid.org/0000-0001-9739-711X

Myung Geun ShinDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea;

Jong Hee ShinDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea;

http://orcid.org/0000-0001-9593-476X

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Abstract

We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.

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Authors’ contributions

This study was designed by SHK. EJW, MYJ, DL, MK, YP collected and analyzed the data. EJW and SHK wrote the initial draft of the manuscript. MGS and JHS supervised the project. All authors revised the manuscript.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and the writing of the paper.

Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters

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Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters

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