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ABSTRACT
Upon crossing between auxotrophic mutants of Streptomyces erythreus BTCC2 producing the antibiotic erythromycin two types of recombinant colonies appear on the selective media—haploid recombinants and heteroclones. The tendency of exlusive appearance of heteroclones by using two closely linked selectable markers is observed. The complementation tests show that independently isolated, phenotypically similar mutations—arg-1,2, ura-1,2, met-1,2 and trp-2,3 affect different but closely linked genes.