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ABSTRACT
A bioprocess of transformation of lactose from natural substrate in batch fermentation of Kluyveromyces marxianus var. lactis MC5 is considered in this paper. A mathematical model which described the kinetics of the process is designed on the basis of experimental data. The control of the batch fermentation process by flow rate of the influent substrate is determined so as to meet given technological requirements for maximum biomass yield, constant concentration of dissolved oxygen and preset yield coefficient.