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ABSTRACT
Stable mutants that are blocked in the production of the aminoglycoside antibiotic spectinomycin were generated by treatment of Streptomyces flavopersicus NRRL 2820 with a combination of N-methyl-N-nitro-N-nitrosoguanidine (NTG) and ultraviolet light. On the basis of their co-synthetic properties in agar-strip and mixed culture methods, the mutants were grouped into five phenotypic groups, and arranged in the most probable linear sequence of metabolic blocks.