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Original Articles

Human Papillomavirus Infection Among Women with Normal Cervical Pap Smear Tests

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Pages 136-138 | Published online: 15 Apr 2014
 

ABSTRACT

Various human papillomaviruses (HPVs) have been strongly implicated as etiological agents in human cervical cancer. The primary method for detection of high-risk HPVs is still the Papanicolaou-stained (Pap) smear. However, the Pap smear has some limitations, including high false-negative rates. Using consensus and specific primer-mediated polymerase chain reaction (PCR), we investigated 55 women with normal cervical cytology. HPV DNA was found in 11 women (20%), including HPV-16 in 6 cases (10.9%), HPV-6 in 3 cases (5.5%), HPV-6/18 in 1 case (1.8%) and HPV-6/33 in 1 case (1.8%). The obtained results demonstrate the importance of careful follow-up and repeated testing for HPV persistence. Moreover, these findings raise the possibility that HPV diagnostics by molecular virology techniques might be useful as an adjunct to Pap smear screening.

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