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ABSTRACT
Investigations suggest that resistance against Trichinella spiralis infection can be modified by application of a separate vaccine preparation, in this case—conjugated total antigen from Trichinella spiralis larvae with hemocyanin from Helix vulgaris. These effects are generally to reduce resistance at the level of the gut, and enhance it against the systemic phase of the infection. The mechanism, which induces these alterations is still not completely clear. Our results showed reduced tissue penetration of the nematode worms in muscles. In addition we have observed solid protective humoral and cellular immune response.