Cancer risk associated single nucleotide polymorphisms of mitochondrial D-loop and 8-hydroxy-2'-deoxyguanosine levels in gastric cancer

ABSTRACT

The accumulation of mutations and single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) is related to gastric carcinogenesis. To evaluate the potential relationships between DNA damage and D-loop SNPs, we measured the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the gastric cancer tissue by immmunostaining. Our data showed that the gastric cancer susceptibility SNP of 16519C was associated with higher 8-OHdG levels. Taken together, the cancer-risk associated D-loop SNPs might initiate carcinogenesis through increasing oxidative damage.

KEYWORDS:

• 8-OHdG
• mtDNA
• D-loop
• SNPs
• gastric cancer

Acknowledgements

We would like to express our sincere thanks to all those who have helped me make this thesis better.

Disclosure statement

No potential conflict of interest was declared by all authors.

Additional information

Funding

Key Basic Research Program of Hebei Province [grant number 14967713D]; Natural Science Foundation of Hebei Province [grant number H2015206461].