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Abstract
Objectives: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant enzymes existed in erythrocytes of type 1 myotonic dystrophy (DM1) patients.
Methods: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were measured in 30 DM1 patients and 15 healthy controls (HCs). The obtained values were correlated with the Muscular Impairment Rating Scale (MIRS) score and creatine kinase (CK).
Results: Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A positive correlation was found between disease duration and MIRS score as well as with glutathione reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels, superoxide dismutase activity was still statistically different from HCs. However, catalase activity was significantly lower only in DM1 patients with increased CK.
Discussion: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may result in conditions favoring oxidative stress and changes in metabolism which together could contribute to muscle wasting.
Disclaimer statements
Contributors All authors contributed equally.
Funding This work was supported by grants from the Ministry of Education, Science and Technological Development of the Republic of Serbia [Grants No. 175083 and 173014].
Conflicts of interest The authors state that there are no conflicts of interest regarding the publication of this article.
Ethics approval The study was approved by the Ethical Board of the Neurology Clinic, University of Medical Sciences, Belgrade, No29/X-5.
Acknowledgements
Special thanks for English language-editing by Dr David R. Jones from Paterson Institute for Cancer Research, The University of Manchester, United Kingdom.