Novel benzopyran derivatives and their therapeutic applications: a patent review (2009–2016)

ABSTRACT

Introduction: The benzopyran derivatives present a wide variety of biological activity and behaviour. At the same time the benzopyran derivatives support their use as therapeutic agents for multiple diseases. Their structural characteristics correlated to physicochemical properties seem to define the extent of the biological activity.

Areas covered: This review summarizes new patents published on new benzopyran derivatives from 2009 to 2016.

Expert opinion: Many benzopyran derivatives have vivo/vitro biological responses. Their clinical evaluation will be critical to assess therapeutic utility. The compounds containing benzopyran moiety is well defined as lead compounds for design of new more promising molecules.

KEYWORDS:

• Benzopyran derivatives
• inhibitors
• anti-inflammatiory
• anticancer
• anti-arthritis
• antibacterial
• anti-Alzheimer activities
• anti-skin diseases activities
• antiviral
• treatment type 2 diabetes and ADPKD

Article highlights

• Patents published on novel benzopyran derivatives from 2009 to 2016 were reviewed.

• New and known benzopyrones derivatives with variety of biological activities were found.

• Benzopyrones can inhibit various different target proteins and enzymes.

• Some benzopyrones can use as lead compounds for the design of novel promising molecules.

• Benzopyrones can be used as tumor-targeting drug carriers.

This box summarizes key points contained in the article.

Declaration of interest

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Additional information

Funding

This paper received funding from the National Natural Science Foundation of China (No. 21572003, 21272008); and the Natural Science Foundation of Anhui Province (No. 1508085QH195).