Mutational spectrum of N-hydroxy-N-acetyl-4-aminobiphenyl at exon 3 of the HPRT gene

Beatriz Zayas-Rivera, Lifang Zhang, Stephen G. Grant, Phouthone Keohavong, Billy W. Day Department of Environmental & Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA.; University of Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania 15238, USA.; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA.

Abstract

4-Aminobiphenyl is a human bladder carcinogen present in many environmental sources, including cigarette smoke. It can be metabolized in two steps to the mutagen N-hydroxy-N-acetyl-4-aminobiphenyl (N-OH-AABP). In this study the mutational spectrum of N-OH-AABP-exposed human lymphoblastoid cells (TK6) was determined using HPRT

Keywords::

Hprt Aminobiphenyl Denaturant Gradient Gel Electrophoresis Mutational Spectrum

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Mutational spectrum of N-hydroxy-N-acetyl-4-aminobiphenyl at exon 3 of the HPRT gene

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Mutational spectrum of N-hydroxy-N-acetyl-4-aminobiphenyl at exon 3 of the HPRT gene

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