Views

CrossRef citations to date

Altmetric

Research Article

Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers

Yu-Chung TsaoDepartment of Occupational Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;Department of Occupational Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan; ;Department of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan;

http://orcid.org/0000-0001-7355-5208

Po-Wen GuCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; ;Department of Laboratory Medicine, Chang Gung Medical Center, Taoyuan, Taiwan;

Su-Hsun LiuDepartment of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan;

http://orcid.org/0000-0002-1151-7983

I-Shiang TzengDepartment of Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan

http://orcid.org/0000-0002-9047-8141

Jau-Yuan ChenDepartment of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan;

Jiin-Chyuan John LuoDepartment of Occupational Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ;College of Medicine, Chang Gung University, Taoyuan, Taiwan; Correspondence[email protected]

Abstract

Context: The mechanism of nickel-induced pathogenesis remains elusive.

Objective: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers.

Materials and methods: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models.

Results: Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment.

Discussion and conclusion: Exposure to high levels of nickel may reduce serum anti-oxidative capacity.

Keywords:

Disclosure statement

The authors have declared no conflicts of interest.

Funding

This work was supported by NSC 85-2331-B-182-106; NSC94-2314-B182-015; NSC95-2314-B182-054-MY2 to JCL.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers

Related Research Data

Information for

Open access

Opportunities

Help and information

Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers

Abstract

Disclosure statement

Funding

Reprints and Corporate Permissions

Academic Permissions

Related Research Data

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature