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Abstract
Context: Thyroid carcinoma is the most common endocrine system malignancy with a fast rising incidence in the last decade for unknown reasons. Fine needle aspiration (FNA) biopsy, the gold standard in thyroid cancer (TC) screening has still its own challenges and in some cases needs a proceeding surgery.
Objective: This review highlights the role of the two most recent “omics” approaches, “metabolomics” and “lipidomics”, in the field of TC research.
Methods: All the previous studies have been extracted from the literature and major concepts were detailed in the field of TC metabolomics and lipidomics.
Results: Metabolomics and lipidomics, have potential in finding biomarkers related to thyroid carcinoma. Among the previous studies, the most important introduced altered tissue metabolites and lipids included glucose and galactose, lactate, Scyllo- and Myo inositol, hypoxanthine, citrate, cholesterol and choline.
Conclusion: Metabolomics methods have been widely used in the field of biomarker discovery in TC and attempts are still in progress to use these methods to find a reliable biomarker panel besides current diagnostic tools.
Acknowledgements
The authors thank the Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences Tehran, Iran for their assistance.
Disclosure statement
The authors report no declarations of interest. The authors alone are responsible for the content and writing of this article.
Funding
We gratefully acknowledge the financial support from the Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences.