Insights into cardiovascular risk and nutritional status in subjects with wheat-related disorders

Abstract

Objective: Wheat-related disorders are a spectrum of disorders associated with different autoimmune and non-autoimmune diseases. However, it is unclear whether these wheat-related disorders lead to adverse health effects such as cardiovascular risk, nutritional deficiencies etc. The objective of the study was to explore the lipid profiles and the nutritional status of subjects with wheat-related disorders to understand the potential threat of wheat on cardiovascular risk and nutritional deficiency.

Method: A total of 1041 subjects who showed wheat-related symptoms were initially tested for the wheat protein antibody panel (Wheat Zoomer (WZ) panel and Coeliac Disease (CD) panel), then for cardiovascular panel and the micronutrient panel at Vibrant America Clinical Laboratory.

Results: Subjects with both Wheat Zoomer positivity (WZ+) and Coeliac Disease positivity (CD+) had significantly low levels of high-density lipoproteins (HDL) (279/483(57.8%) and 29/47(61.7%) respectively), but only subjects with WZ + had low levels of Apo A1 (44/424(9.5%)), and high levels of Omega 6 fatty acids (53/334(15.9%)). None of the micronutrients tested showed a significant imbalance in WZ + subjects.

Conclusion: Subjects with positive serology for WZ have deranged blood lipid profiles but did not show any significant micronutrient deficiency. Hence, our results showcase a significant association of wheat-related disorders to cardiovascular risk.

Keywords:

• Wheat sensitivity
• coeliac disease
• lipid profile
• micro nutrients
• cardiovascular risk

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Disclosure statement

Siriwardhane is an employee of Vibrant America LLC. Krishna, Devarajan, Ranganathan, Jayaraman, Wang, Bei, Rajasekaran, Krishnamurthy are employees of Vibrant Sciences LLC., CA, USA

Additional information

Funding

We acknowledge Vibrant America LLC for supporting this research.