Subjects with microvascular angina have longer GT repeats polymorphism in the haem oxygenase-1 gene promoter

Abstract

Objective: Few studies have investigated haem oxygenase-1 gene (HMOX1) promoter polymorphism in microvascular angina (MVA).

Materials and methods: HMOX1 promoter (GT)_n repeats were examined in healthy controls (N = 220) and MVA subjects (N = 181).

Results: The distribution of genotype of SS, SL and LL were significantly different in MVA (17%, 51%, 33%) vs. normal controls (35%, 46%, 20%) (p < 0.001, S allele: ≤30 repeats, L allele: >30 repeats). In multivariate analysis, carrier of L allele (odds ratio 2.772, p < 0.001) was a significant predictor for the diagnosis of MVA.

Conclusions: Subjects with MVA had longer HMOX1 promoter (GT)_n repeats than the healthy controls.

Trial registration number: NCT01198730 at https://clinicaltrials.gov

Keywords:

• Haem oxygenase-1 gene (HMOX1)
• microvascular angina (MVA)
• promoter polymorphism
• cardiac syndrome X
• promoter (GT)_n repeats

Acknowledgements

The authors thank the Biostatistics Task Force of Taichung Veterans General Hospital for statistical support.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported in part by grants from Taichung Veterans General Hospital, Taiwan [TCVGH-1063102B, 1073108C, 1067328D, 1067314C].