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Original Articles

Au-TiO2 nanoparticles exposure induced oxidative stress and neurotoxicity in rat

, , , , , , , , & show all
Pages 240-247 | Received 05 May 2020, Accepted 12 Jan 2021, Published online: 03 Feb 2021
 

Abstract

Context

The Au-TiO2NPs have a wide range of applications and can easily enter the cells. Due to their properties, they can cause toxicity.

Objective

It was aimed to test the toxic effects of Au-TiO2 NPs in the brain, heart, kidney and liver of rats in this work.

Materials and methods

All used rats in this work were treated using diverse concentrations (doses) of NPs (100 and 200 mg/kg bw) for 21 days. SOD, CAT, AChE activities and MDA, H2O2, NO contents were evaluated in different organs.

Results

The Au-TiO2 NPs exposure induced biochemical changes in different organs of rats in view of oxidative stress and neurotoxicity by the alteration of the activity of the enzyme of neurotransmitter (AChE activity).

Conclusion

The Au-TiO2 NPs have the potential to interact with rat’s biochemical status and cause undesirable effects. One of those damaging effects was oxidative stress and neurotoxicity.

Clinical significance

The study signifies the impact of usage of Au-TiO2 NPs in the medical field for further exploration.

Acknowledgements

Taif University Researchers Supporting Project number (TURSP-2020/28), Taif University, Taif, Saudi Arabia.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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