162
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Assessment of the relationship between semaphorin4D level and recurrence after catheter ablation in paroxysmal atrial fibrillation

, , , , , & show all
Pages 468-476 | Received 25 Feb 2021, Accepted 11 Apr 2021, Published online: 28 Apr 2021
 

Abstract

Objective

Semaphorin4D (Sema4D), a novel integral membrane glycoprotein, plays a role in atherosclerosis, angiogenesis and chronic inflammation. Elevated levels of sema4D were presented in myocardial infarction, heart failure and atrial fibrillation. Aim of the study was to investigate the relation between sema4D and recurrence after catheter ablation (CA) in paroxysmal AF.

Methods

The present study included 161 paroxysmal AF patients (PAF) (101 patients undergone CA) and 60 healthy subjects. Serum levels of sema4D were measured and study participants were followed-up for 3 months and 1 year since CA in terms of recurrence respectively.

Results

Sema4D levels were significantly elevated in the recurrent group compared to the non-recurrent PAF patients (p < 0.001). Sema4D was importantly positively correlated with both left atrial volume index (r = 0.51, p < 0.013) and high sensitive C-reactive protein (r = 0.38), p < 0.011). In multivariate analysis, sema4D [odds ratio (OR) = 1.23, 95% CI 1.11–1.42; p < 0.001] and left atrial diameter (OR = 1.13, 95% CI 1.02–1.23; p = 0.012) were found to be significant independent risk parameters for recurrence.

Conclusions

Sema4D is a novel biomarker that may help to identify individuals with recurrence after CA procedure in long term period in PAF.

Disclosure statement

The authors declared no conflicts of interest with respect to the research, authorship, and/or publication of this article.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.