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Abstract
In this article the importance of study design will be emphasized, statistical methods for analysing the data are described and some of the implications of these method are discussed. How these issues relate to the use of SpIN and SnOUT rules are reviewed.
Funding
The author reported there is no funding associated with the work featured in this article.
Data availability statement
No data deposited. Data in Box 1 available in McCann and Ames paper.