HTLV-I-associated myelopathy: Are ferritin, S100β protein, or guanine nucleotides CSF markers of disease?

Abstract

In southern Brazil, there is an endemic high prevalence foci of HTLV-I and HTLV-II infection. HTLV-infected individuals may develop HAM/TSP.Little is known about HAM/TSP pathogenesis and there is a lack of disease progression markers. This study investigated ferritin, S-100 &#103 protein, and guanine nucleotides (GN) concentrations in the CSF of 18 patients with HAM/TSP. In HAM/TSP patients, concentrations of ferritin and S100 &#103 were increased, whereas GMP was reduced. CSF ferritin, S100 &#103 , and GN are potential markers for HAM/TSP.

• Htlv
• S100beta
• Ferritin
• Guanine Nucleotides