Quantitative assessment of spasticity in human T-cell lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis

JR Zunt Departments of Neurology, University of Washington School of Medicine, Seattle, Washington, USA; Departments of Medicine, University of Washington School of Medicine, Seattle, Washington, USA

SM Montano Instituto de Ciencias Neurológicas, Lima, Perú

JOV Alarcón Universidad Nacional Mayor de San Marcos, Lima, Perú

WT Jr, Longstreth Departments of Neurology, University of Washington School of Medicine, Seattle, Washington, USA; Departments of Epidemiology, University of Washington School of Medicine, Seattle, Washington, USA

R Price, Departments of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA

and KK Holmes Departments of Epidemiology, University of Washington School of Medicine, Seattle, Washington, USA; Departments of Medicine, University of Washington School of Medicine, Seattle, Washington, USA; Departments of Center for AIDS and STD, University of Washington School of Medicine, Seattle, Washington, USA

Abstract

People with human T-cell lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis (HAM/TSP) develop spasticity. The authors examined 34 patients with HAM/TSP in Perú using a device that measures tone in the gastroc-soleus-Achilles tendon unit and provides a quantitative spasticity assessment (QSA). Tone in the 34 patients was more than double that of women with asymptomatic HTLV-I infection. The device may help to track progression in HTLV-I infection.

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This work was supported by NIH grants K23-AI01600, TW00679, and AI0714P, Fogarty International grant T22-TW00001, and the University of Washington Center for AIDS Research (CFAR) grant AI27757.

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Quantitative assessment of spasticity in human T-cell lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis

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Quantitative assessment of spasticity in human T-cell lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis

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