Relative hyperperfusion by SPECT in a family with a presenilin 1 (T245P) mutation

Terri Edwards-Lee Harbor-UCLA Medical Center Department of Neurology, David Geffen School of Medicine at UCLA Department of Neurology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USACorrespondence[email protected]

Johnny Wen Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, California State University at Long Beach Department of Psychology, Torrance, CA, USA

Julia A. Chung Harbor-UCLA Medical Center Department of Psychiatry, David Geffen School of Medicine at UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA

Panukorn Vasinrapee Harbor-UCLA Medical Center Department of Radiology, David Geffen School of Medicine at UCLA Department of Radiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA

Frederick S. Mishkin Harbor-UCLA Medical Center Department of Radiology, David Geffen School of Medicine at UCLA Department of Radiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA

Abstract

Clinical characteristics of autosomal dominant Alzheimer's disease often differ clinically from sporadic disease with the onset of seizures, spasticity and myoclonus early in the disease course. Similarly imaging characteristics may also differ. We report the findings of relative hyperperfusion by Tc-99m HMPAO SPECT in the medial orbitofrontal cortex and anterior temporal lobe in four affected family members carrying a presenilin 1 mutation. SPECT of the four individuals was compared to an age-matched normal database. We speculate that the findings of relative medial orbitofrontal and anterior temporal lobe hyperperfusion may be a marker of early onset Alzheimer's disease in this family.

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This study was sponsored by in part a Pilot Research Grant from the Society of Nuclear Medicine and the Harbor UCLA General Clinical Research Center.

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Relative hyperperfusion by SPECT in a family with a presenilin 1 (T245P) mutation

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Relative hyperperfusion by SPECT in a family with a presenilin 1 (T245P) mutation

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