Auditory pathways fail to re-establish normal cortical activation patterns in response to binaural stimulation following a unilateral lesion of the inferior colliculus

Abstract

The aim of this study was to investigate cortical activation in response to binaural stimulus presentations in an individual (FX) with a circumscribed traumatic hemorrhagic lesion of the right inferior colliculus. FX and control subjects were exposed to complex sounds while undergoing a functional magnetic resonance imaging assessment. Whereas normally-hearing individuals show well-balanced bilateral activation patterns in response to binaural auditory stimulation, the same stimuli produced stronger activation in the left hemisphere in FX. Combined with previous data, these findings reinforce the notion that the inferior colliculus is an essential auditory relay and that its loss cannot be significantly compensated.

Keywords:

• Functional MRI
• Auditory pathways
• Inferior colliculus
• Lesion
• Brain reorganization

This study was supported by grants from the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes for Health Research (CIHR) and the Fonds de Recherche en Santé du Québec (FRSQ). Disclosure: The authors have no conflicts of interest to report.