Emotion circuits differentiate symptoms of psychosis versus mania in adolescents

Annie M. BrennanBrain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, University of Sydney at Westmead, Sydney, NSW, Australia;Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, AustraliaCorrespondence[email protected]

Cassandra HainsworthDepartment of Psychological Medicine, Children’s Hospital at Westmead, Sydney, NSW, Australia

Jean StarlingDiscipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia;Walker Unit, Concord Centre for Mental Health, Concord West, NSW, Australia

Mayuresh S. KorgaonkarBrain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, University of Sydney at Westmead, Sydney, NSW, Australia;Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia

Anthony W. F. HarrisBrain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, University of Sydney at Westmead, Sydney, NSW, Australia;Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia

Leanne M. WilliamsBrain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, University of Sydney at Westmead, Sydney, NSW, Australia;Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia;Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA

Abstract

The diagnostic boundary between schizophrenia and bipolar disorder can be unclear, particularly with early onset. We assessed if emotion brain circuits differentiate psychosis versus mania symptoms in a series of six early onset patients. Symptoms were dissociated by direction, awareness condition, and brain regions. Greater psychosis symptoms were correlated with greater prefrontal, anterior cingulate, amygdala, and fusiform face area activation during masked fear processing. By contrast, greater mania symptoms were correlated with less amygdala activation during unmasked fear and happy processing. This suggests emotion dysfunction in schizophrenia versus bipolar disorder may arise from partially distinct neural mechanisms of susceptibility.

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Emotion circuits differentiate symptoms of psychosis versus mania in adolescents

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Emotion circuits differentiate symptoms of psychosis versus mania in adolescents

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