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Neurocase
Behavior, Cognition and Neuroscience
Volume 24, 2018 - Issue 4
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Articles

A neuropathologic diagnosis of Alzheimer’s disease in an older adult with HIV-associated neurocognitive disorder

Joanna HellmuthMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, CA, USACorrespondence[email protected]
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,
Benedetta MilaniniMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, CA, USAView further author information
,
Eliezer MasliahDepartments of Neurosciences and Pathology, University of California, San Diego, California, CA, USAView further author information
,
Maria Carmela TartagliaUniversity of Toronto, Tanz Centre for Research in Neurodegenerative Diseases, Toronto, CanadaView further author information
,
Miranda B. DunlopDepartment of Internal Medicine, University of California, San Francisco, California, CA, USAView further author information
,
David J. MooreDepartment of Psychiatry, University of California, San Diego, California, CA,USAView further author information
,
Shireen JavandelMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, CA, USAView further author information
,
Saskia DeVaughnMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, CA, USAView further author information
&
Victor ValcourMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, CA, USAView further author information
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Pages 213-219 | Received 17 Apr 2018, Accepted 10 Sep 2018, Published online: 10 Oct 2018
 
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ABSTRACT

We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer’s disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by NIH/NIMH grants K23MH114724 (JH).

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