Temporal–occipital glioblastoma presenting with Alice in Wonderland Syndrome in a patient with a long-time history of migraine without aura

Giulio MastriaDepartment of Human Neurosciences, “Sapienza” University of Rome, Rome, Italy

Valentina ManciniDepartment of Human Neurosciences, “Sapienza” University of Rome, Rome, ItalyCorrespondence[email protected]

http://orcid.org/0000-0003-4411-896X

Alessandro ViganòDepartment of Human Neurosciences, “Sapienza” University of Rome, Rome, Italy;Department of Anatomy, Histology, Forensic Medicine, Orthopaedics, Sapienza University of Rome, Rome, Italy

Rita De SanctisDepartment of Medical Oncology and Hematology, Humanitas Cancer Center and Research Hospital, IRCCS, Rozzano, Milan, Italy;Research Hospital, IRCCS, Rozzano, Milan,Italy

Federica LetteriDepartment of Human Neurosciences, “Sapienza” University of Rome, Rome, Italy

Massimiliano ToscanoDepartment of Human Neurosciences, “Sapienza” University of Rome, Rome, Italy

Vittorio Di PieroDepartment of Human Neurosciences, “Sapienza” University of Rome, Rome, Italy;University Consortium for Adaptive Disorders and Head Pain – UCADH, Pavia, Italy

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ABSTRACT

Alice in Wonderland Syndrome (AIWS) is a rare perceptual disorder characterized by an erroneous perception of the body or the surrounding space. AIWS may be caused by different pathologies, ranging from infections to migraine. We present the case of a 54-year-old man, with a long-time history of migraine without aura, diagnosed with AIWS due to a glioblastoma located in the left temporal–occipital junction. To date, this is the first case of AIWS caused by glioblastoma. This case suggests that to exclude aura-mimic phenomena, a careful diagnostic workup should always be performed even in patients with a long-time history of migraine.

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Temporal–occipital glioblastoma presenting with Alice in Wonderland Syndrome in a patient with a long-time history of migraine without aura

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Temporal–occipital glioblastoma presenting with Alice in Wonderland Syndrome in a patient with a long-time history of migraine without aura

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