Hyperparathyroidism and cerebral calcifications:a case report

ABSTRACT

The evidence of hyperparathyroidism associated with cerebral calcifications is rare. We report a case with primary hyperparathyroidism (PHPT) and cerebral calcifications. A 63-year-old female patient with a history of hypertension presented to the neurology department due to bradykinesia and declining memory for one year.   Cranial CT and magnetic resonance imaging (MRI) scan revealed symmetrical calcifications in the basal ganglia, dentate nucleus of the cerebellum and in the gray and white matter junction. In the literature review, a total of 6 patients with PHPT had cerebral calcifications. Parathyroidectomy may provide a significant remission of cerebral calcifications in a patient with PHPT.

KEYWORDS:

• Hyperparathyroidism
• Cerebral calcifications
• Parkinsonism

Abbreviations

BCC: Bilateral Cerebral Calcifications; CT: Computed Tomography; LUL: Left Upper Limb; PTH: Parathyroid Hormone; PHPT: Primary Hyperparathyroidism; MRI: Magnetic Resonance Imaging

Authors contributions

1) Research project, Conception, Organization: Hongyan Xu; Execution: Hongyan Xu, Haoqiang Qin, Shaohua Chen, Mingjian Guan,Shengwu Zhong,Qitan He.2) Statistical Analysis: Design and Execution: Honyan Xu, Shaohua Chen; Review and Critique: Hongyan Xu, Haoqiang Qin. 3) Manuscript: First draft: Hongyan Xu; Review and Critique: Hongyan Xu, Haoqiang Qin.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.