Mental impairment and attention deficit hyperactivity disorder in a family with FRAXF

Abstract

A mother and her three children with fragile X syndrome (FRAXF fragile site), shown by cytogenetic and molecular genetic methods, were neuro psychiatrically and psychometrically evaluated. All individuals exhibited clear learning disability, as well as attention deficit hyperactivity disorder. The findings suggest that these clinical attributes, particularly mental impairment, may be a phenotypic expression of the FRAXF fragility.