2
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Multiple Chemical Sensitivity--An Elevation of Enzyme Induction Thresholds

Pages 337-342 | Published online: 13 Jul 2009
 

Abstract

The hypothesis was advanced in previous papers that the symptoms of multiple chemical sensitivity (MCS) are due to the presence of thresholds, or increases in thresholds, in detoxication processes, so that these are not activated by low exposures to xenobiotic chemicals. Here the argument is taken further forward, to propose that thresholds for the induction of the enzymes which mediate the biotransformation of xenobiotics, and the elevation of those thresholds above normal levels, are the basic parameters giving rise to the symptoms of MCS. Some theoretical and experimental evidence is quoted to support the existence of these thresholds, and examples are given of how many of the characteristics of MCS can be expected to follow from the application of these ideas, which do not conflict with orthodox toxicology.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.